Second-generation antipsychotics and pregnancy complications
نویسندگان
چکیده
منابع مشابه
Interactions between antiepileptics and second-generation antipsychotics.
INTRODUCTION Pharmacokinetic and pharmacodynamic drug interactions (DIs) can occur between antiepileptics (AEDs) and second-generation antipsychotics (SGAPs). Some AED and SGAP pharmacodynamic mechanisms are poorly understood. AED-SGAP combinations are used for treating comorbid illnesses or increasing efficacy, particularly in bipolar disorder. AREAS COVERED This article provides a comprehen...
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Antipsychotic-induced extrapyramidal adverse effects are well recognized in the context of first-generation antipsychotic drugs. However, the introduction of second-generation antipsychotics, with atypical mechanism of action, especially lower dopamine receptors affinity, was met with great expectations among clinicians regarding their potentially lower propensity to cause extrapyramidal syndro...
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Peluso et al report on the differential effect of first-generation antipsychotics (FGAs) v. second-generation antipsychotics (SGAs) in ameliorating or exacerbating extrapyramidal side-effects (EPS) in a secondary analysis of the CUtLASS-1 trial data. They report their findings as ‘essentially null’ and mention that there is weak evidence for clinically significant differences in emergent or rel...
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INTRODUCTION Combinations of newer antidepressants and second-generation antipsychotics (SGAs) are frequently used by clinicians. Pharmacokinetic drug interaction (PK DI) and poorly understood pharmacodynamic (PD) drug interaction (PD DI) can occur between them. AREAS COVERED This paper comprehensively reviews PD DI and PK DI studies. EXPERT OPINION More PK DI studies are needed to better e...
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The modern era in the treatment of psychotic disorders began in the early ’50s with the discovery of chlorpromazine. This was a real revolution and maybe the most important single contribution in the treatment of psychiatric illnesses. Clorpromazine and the subsequent drugs that were introduced in the next 10–15 years, shared a common element in that they all were potent dopamine2(D2) receptor ...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2019
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-019-02769-z